Friday, December 31, 2010

Healthtips-AIDS immunity is all in the proteins!

It is the proteins which help some HIV infected people not end up having AIDSA large-scale genetic analysis has suggested that tiny changes in the structure of a protein help the immune system to recognize and destroy infected cells, reports Nature.

Most people who contract HIVeventually end up with full-blown AIDS as the virus replicates in their cells, reaching very high levels and damaging their immune systems.

However, the virus does not progress to this stage in about 1 out of every 300 infected people. These ''HIV controllers'' do not require treatment, because their bodies suppress the replicationof the virus.

Bruce Walker of the Harvard University in Charlestown, first thought of carrying out the study when he recognized the clinical value of such HIV controllers.

"I realized that we could create a cohort by going directly to physicians around the world, and I thought we should figure out what is genetically unique about people who do well compared with people who do badly," he said.

Walker and his colleagues sampled the DNA of more than 900 HIV controllers. They compared it with the genetic code of 2,600 individuals with normal HIV infections, using a technique called a genome-wide association study (GWAS).

The GWAS tested single nucleotide polymorphism (SNP) variations - changes in one letter of DNA - at a million points in the genomes of these individuals, and found more than 300 sites that were statistically associated with control of HIV.

All the sites identified are in a region of the genome that codes for proteins involved in immune response, called HLA proteins. The researchers used regression analyses to narrow their search down to the four sites most strongly linked to HIV immunity.

It isn''t possible to tell from the statistics alone whether these sites cause HIV immunity themselves or are simply closely associated with others that do. But using a detailed map of the HLA regions of the genome, created as part of an earlier diabetes study2, the team pinpointed specific amino acids in the protein HLA-B that differed between controllers and people with normal infections.

These amino acids seemed to be behind the ability to control the virus.

"Out of the three billion nucleotides [that make up the human genome], we narrowed it down to a handful of amino acids that define the difference, each coded for by just three nucleotides," said Walker.
Changes in the amino acids identified by Walker''s team altered how HLA-B presents viral peptides from HIV to the immune system, but how this process differs between controllers and people with normal HIV infetions remains unclear.-ANI

BABY FOOD RECIPES

BABY FOOD RECIPES - CHICKEN HEARTS APPLE
Baby food recipes

Material:
250 grams of chicken liver
2 apples, peeled, seeded, chopped
1 carrot, peeled and cut into pieces
3 pieces potatoes, peeled and cut into pieces
2 stalks celery, chopped
3 tablespoons green peas

Directions:
1. Cook all ingredients until cooked.
2. Drain and puree (or chopped finely for children ages 8 months and up)

BABY FOOD RECIPES - FISH APPLE
Baby food recipes

Material:
2 pieces of fish fillets
2 apples, peeled, cut into pieces

Directions:
1. Boil the ingredients until cooked. Drain and puree.

Note:
For children 8 months, the food should not be crushed but only finely chopped. It is good to stimulate the growth of teeth and to train the muscles of the mouth and gums to bite.

BABY FOOD RECIPES - CARAPPEAR
Baby food recipes

Material:
2 stalks carrots, peeled, cut into pieces
2 apples, peeled, cut into pieces
2 pieces of pear, peeled and cut into pieces

Directions:
1. Kl Boil carrots for 10 minutes, then amsukkan apple and pear. Cook until soft.
2. Drain and puree (or chopped finely for children ages 8 months and up)

BABY FOOD RECIPES - steamed fish
Baby food recipes

Material:
1 snapper fillet (or other fish species, according to taste)

Directions:
1. Steam the fish until cooked and then mashed.
2. Can be mixed with pureed vegetables (carrots, broccoli, etc.).

BABY FOOD RECIPES - Broccoli POTATO
Baby food recipes

Material:
7 broccoli florets, discarding the stem
2 potatoes, peeled, cut into pieces
Chicken broth / meat taste (only boiled water chicken / meat, without salt or other seasonings)

Directions:
1. Steam the broccoli and potatoes until cooked.
2. Blend the two ingredients with the processor / blender.
3. Give the broth to taste.

BABY FOOD RECIPES - VEGETABLE INTERFERENCE
Baby food recipes

Material:
1 carrot, peeled, cut into pieces
1 piece of potato, peeled, cut into pieces
2 tablespoons green peas (can be replaced other green vegetables, eg broccoli,
zuchini, celery, etc.)
Chicken broth / meat taste (only boiled water chicken / meat, without garammaupun other seasonings)

Directions:
1. Boiled / steamed until cooked all the ingredients and puree.
2. Give the chicken broth / meat taste.

BABY FOOD RECIPES - CHICKEN SOUP
Baby food recipes

Material:
1 piece of chicken thighs, remove skin, cut meat into pieces (bones were not removed)
1 stalk celery, chopped
2 potatoes, peeled, cut into pieces
1 stick carrot, peeled, cut into pieces
2 tablespoons green peas
500 ml water

Directions:
1. Cook all ingredients until cooked.
2. Discard the chicken bones, then puree all ingredients

BABY FOOD RECIPES - puree CARROT
Baby food recipes

Material:
2 medium carrots, peeled
Boiled water to taste

Directions:
1. Steam the carrots until tender then puree. Add water as needed.
2. Presentation: Give the carrot puree as single or mixed foods
with pulp POTATO / SWEET POTATOES porridge.

BABY FOOD RECIPES - pea puree
Baby food recipes

Material:
250 grams of fresh or frozen peas

Directions:
1. Boil peas until cooked and then mashed.
2. Strain the rough skin so do not take part inedible.
3. Presentation: Give peas puree as a single food or
mixed with porridge POTATO / SWEET POTATOES porridge.