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Thursday, October 21, 2010
Turmeric boosts effect of chemo drug in head and neck cancer
In India, women for years have been using turmeric for medicinal purposes, as an anti-aging agent rubbed into their skin, to treatcramps during menstruation, as a poultice on the skin to promote wound healing and as an additive in cosmetics, said scientist Eri Srivatsan, an adjunct professor of surgery and a Jonsson Cancer Center researcher.
Srivatsan, along with Dr. Marilene Wang, a professor of head and neck surgery, lead author of the study and a Jonsson Cancer Center researcher, has been studying curcumin and its anti-cancer properties for six years.
A 2005 study by Wang and Srivatsan first showed that curcumin suppressed the growth of head and neck cancer cells, first in cells and then in mouse models. In the animal studies, the curcumin was applied directly onto the tumors in paste form because it did not dissolve in saline, which would have allowed it to be injected.
In need of a better way to deliver the curcumin, the team collaborated with Dr. Kapil Mehta of M.D. Anderson CancerCenter and found that encapsulating the curcumin in a liposome, an artificially prepared vehicle that enclosed the spice component within its membrane, made the treatment injectable.
The curcumin was injected into the tail vein of a mouse, where it circulated into the blood stream, slowing down and eventually stopping the cancer growth, a study in 2008 found.
"This was a very positive finding, developing an efficient way to deliver the treatment," Wang said. "Our study also showed that the curcumin was very well tolerated."
In this study, the team wanted to combine the curcumin with the chemotherapeutic drug Cisplatin, which is very toxic at the doses needed to fight head and neck cancers, damaging kidneys, the ears and the bone marrow. They hoped that if they added curcumin to the mix, they might be able to lower the Cisplatin dose and cause less organ damage. Their finding, that the curcumin made the Cisplatin work better, was very promising, Wang said.
"We knew that both the curcumin and the Cisplatin, when given alone, had an effect against head and neck cancers. This finding that curcumin enhances Cisplatin means that, in the future, we may be able to give this chemotherapy in lower doses.," Wang said.
The study noted that "the mechanisms of the two agents through different growth signaling pathways suggest potential for the clinical use of sub-therapeutic doses of Cisplatin in combination with curcumin, which will allow effective suppression of tumor growth while minimizing the toxic side effects."
The study found that curcumin suppressed head and neck cancer growth by regulating cell cycling, Srivatsan said. It binds to an enzyme and prevents the enzyme IKK, an inhibitor of kappa B kinase, from activating a transcription factor called nuclear factor kappa B (NFêB), which promotes cancer growth. Cisplatin''s suppressive action involves a different pathway through the tumor suppressor proteins p16 and p53, both proteins that again inhibit the activity of cancer growth promoter NFêB.
"We needed to know the mechanism to help us translate this from the lab into the clinic. That information will help us make better decisions on how to design therapies," Wang said.
The study appears in the October issue of the journal Molecular Cancer Therapeutics.--ANI
A 2005 study by Wang and Srivatsan first showed that curcumin suppressed the growth of head and neck cancer cells, first in cells and then in mouse models. In the animal studies, the curcumin was applied directly onto the tumors in paste form because it did not dissolve in saline, which would have allowed it to be injected.
In need of a better way to deliver the curcumin, the team collaborated with Dr. Kapil Mehta of M.D. Anderson CancerCenter and found that encapsulating the curcumin in a liposome, an artificially prepared vehicle that enclosed the spice component within its membrane, made the treatment injectable.
The curcumin was injected into the tail vein of a mouse, where it circulated into the blood stream, slowing down and eventually stopping the cancer growth, a study in 2008 found.
"This was a very positive finding, developing an efficient way to deliver the treatment," Wang said. "Our study also showed that the curcumin was very well tolerated."
In this study, the team wanted to combine the curcumin with the chemotherapeutic drug Cisplatin, which is very toxic at the doses needed to fight head and neck cancers, damaging kidneys, the ears and the bone marrow. They hoped that if they added curcumin to the mix, they might be able to lower the Cisplatin dose and cause less organ damage. Their finding, that the curcumin made the Cisplatin work better, was very promising, Wang said.
"We knew that both the curcumin and the Cisplatin, when given alone, had an effect against head and neck cancers. This finding that curcumin enhances Cisplatin means that, in the future, we may be able to give this chemotherapy in lower doses.," Wang said.
The study noted that "the mechanisms of the two agents through different growth signaling pathways suggest potential for the clinical use of sub-therapeutic doses of Cisplatin in combination with curcumin, which will allow effective suppression of tumor growth while minimizing the toxic side effects."
The study found that curcumin suppressed head and neck cancer growth by regulating cell cycling, Srivatsan said. It binds to an enzyme and prevents the enzyme IKK, an inhibitor of kappa B kinase, from activating a transcription factor called nuclear factor kappa B (NFêB), which promotes cancer growth. Cisplatin''s suppressive action involves a different pathway through the tumor suppressor proteins p16 and p53, both proteins that again inhibit the activity of cancer growth promoter NFêB.
"We needed to know the mechanism to help us translate this from the lab into the clinic. That information will help us make better decisions on how to design therapies," Wang said.
The study appears in the October issue of the journal Molecular Cancer Therapeutics.--ANI
Posted by
sri sultan hamengkubuwono[
BABY FOOD RECIPES
BABY FOOD RECIPES - CHICKEN HEARTS APPLE
Baby food recipes
Material:
250 grams of chicken liver
2 apples, peeled, seeded, chopped
1 carrot, peeled and cut into pieces
3 pieces potatoes, peeled and cut into pieces
2 stalks celery, chopped
3 tablespoons green peas
Directions:
1. Cook all ingredients until cooked.
2. Drain and puree (or chopped finely for children ages 8 months and up)
BABY FOOD RECIPES - FISH APPLE
Baby food recipes
Material:
2 pieces of fish fillets
2 apples, peeled, cut into pieces
Directions:
1. Boil the ingredients until cooked. Drain and puree.
Note:
For children 8 months, the food should not be crushed but only finely chopped. It is good to stimulate the growth of teeth and to train the muscles of the mouth and gums to bite.
BABY FOOD RECIPES - CARAPPEAR
Baby food recipes
Material:
2 stalks carrots, peeled, cut into pieces
2 apples, peeled, cut into pieces
2 pieces of pear, peeled and cut into pieces
Directions:
1. Kl Boil carrots for 10 minutes, then amsukkan apple and pear. Cook until soft.
2. Drain and puree (or chopped finely for children ages 8 months and up)
BABY FOOD RECIPES - steamed fish
Baby food recipes
Material:
1 snapper fillet (or other fish species, according to taste)
Directions:
1. Steam the fish until cooked and then mashed.
2. Can be mixed with pureed vegetables (carrots, broccoli, etc.).
BABY FOOD RECIPES - Broccoli POTATO
Baby food recipes
Material:
7 broccoli florets, discarding the stem
2 potatoes, peeled, cut into pieces
Chicken broth / meat taste (only boiled water chicken / meat, without salt or other seasonings)
Directions:
1. Steam the broccoli and potatoes until cooked.
2. Blend the two ingredients with the processor / blender.
3. Give the broth to taste.
BABY FOOD RECIPES - VEGETABLE INTERFERENCE
Baby food recipes
Material:
1 carrot, peeled, cut into pieces
1 piece of potato, peeled, cut into pieces
2 tablespoons green peas (can be replaced other green vegetables, eg broccoli,
zuchini, celery, etc.)
Chicken broth / meat taste (only boiled water chicken / meat, without garammaupun other seasonings)
Directions:
1. Boiled / steamed until cooked all the ingredients and puree.
2. Give the chicken broth / meat taste.
BABY FOOD RECIPES - CHICKEN SOUP
Baby food recipes
Material:
1 piece of chicken thighs, remove skin, cut meat into pieces (bones were not removed)
1 stalk celery, chopped
2 potatoes, peeled, cut into pieces
1 stick carrot, peeled, cut into pieces
2 tablespoons green peas
500 ml water
Directions:
1. Cook all ingredients until cooked.
2. Discard the chicken bones, then puree all ingredients
BABY FOOD RECIPES - puree CARROT
Baby food recipes
Material:
2 medium carrots, peeled
Boiled water to taste
Directions:
1. Steam the carrots until tender then puree. Add water as needed.
2. Presentation: Give the carrot puree as single or mixed foods
with pulp POTATO / SWEET POTATOES porridge.
BABY FOOD RECIPES - pea puree
Baby food recipes
Material:
250 grams of fresh or frozen peas
Directions:
1. Boil peas until cooked and then mashed.
2. Strain the rough skin so do not take part inedible.
3. Presentation: Give peas puree as a single food or
mixed with porridge POTATO / SWEET POTATOES porridge.
Baby food recipes
Material:
250 grams of chicken liver
2 apples, peeled, seeded, chopped
1 carrot, peeled and cut into pieces
3 pieces potatoes, peeled and cut into pieces
2 stalks celery, chopped
3 tablespoons green peas
Directions:
1. Cook all ingredients until cooked.
2. Drain and puree (or chopped finely for children ages 8 months and up)
BABY FOOD RECIPES - FISH APPLE
Baby food recipes
Material:
2 pieces of fish fillets
2 apples, peeled, cut into pieces
Directions:
1. Boil the ingredients until cooked. Drain and puree.
Note:
For children 8 months, the food should not be crushed but only finely chopped. It is good to stimulate the growth of teeth and to train the muscles of the mouth and gums to bite.
BABY FOOD RECIPES - CARAPPEAR
Baby food recipes
Material:
2 stalks carrots, peeled, cut into pieces
2 apples, peeled, cut into pieces
2 pieces of pear, peeled and cut into pieces
Directions:
1. Kl Boil carrots for 10 minutes, then amsukkan apple and pear. Cook until soft.
2. Drain and puree (or chopped finely for children ages 8 months and up)
BABY FOOD RECIPES - steamed fish
Baby food recipes
Material:
1 snapper fillet (or other fish species, according to taste)
Directions:
1. Steam the fish until cooked and then mashed.
2. Can be mixed with pureed vegetables (carrots, broccoli, etc.).
BABY FOOD RECIPES - Broccoli POTATO
Baby food recipes
Material:
7 broccoli florets, discarding the stem
2 potatoes, peeled, cut into pieces
Chicken broth / meat taste (only boiled water chicken / meat, without salt or other seasonings)
Directions:
1. Steam the broccoli and potatoes until cooked.
2. Blend the two ingredients with the processor / blender.
3. Give the broth to taste.
BABY FOOD RECIPES - VEGETABLE INTERFERENCE
Baby food recipes
Material:
1 carrot, peeled, cut into pieces
1 piece of potato, peeled, cut into pieces
2 tablespoons green peas (can be replaced other green vegetables, eg broccoli,
zuchini, celery, etc.)
Chicken broth / meat taste (only boiled water chicken / meat, without garammaupun other seasonings)
Directions:
1. Boiled / steamed until cooked all the ingredients and puree.
2. Give the chicken broth / meat taste.
BABY FOOD RECIPES - CHICKEN SOUP
Baby food recipes
Material:
1 piece of chicken thighs, remove skin, cut meat into pieces (bones were not removed)
1 stalk celery, chopped
2 potatoes, peeled, cut into pieces
1 stick carrot, peeled, cut into pieces
2 tablespoons green peas
500 ml water
Directions:
1. Cook all ingredients until cooked.
2. Discard the chicken bones, then puree all ingredients
BABY FOOD RECIPES - puree CARROT
Baby food recipes
Material:
2 medium carrots, peeled
Boiled water to taste
Directions:
1. Steam the carrots until tender then puree. Add water as needed.
2. Presentation: Give the carrot puree as single or mixed foods
with pulp POTATO / SWEET POTATOES porridge.
BABY FOOD RECIPES - pea puree
Baby food recipes
Material:
250 grams of fresh or frozen peas
Directions:
1. Boil peas until cooked and then mashed.
2. Strain the rough skin so do not take part inedible.
3. Presentation: Give peas puree as a single food or
mixed with porridge POTATO / SWEET POTATOES porridge.